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DOI 10.1007/s00204-016-1845-1 REVIEW ARTICLE Evidence‑based selection of training compounds for use in the ... Thus, the training compounds selection offered a valuable tool to profile DILI mechanisms and to interrogate existing and novel in vitro systems for the prediction of human DILI. Keywords Drug-induced liver injury ...
https://link.springer.com/content/pdf/10.1007/s00204-016-1845-1.pdfThus, the training compounds selection offered a valuable tool to profile DILI mechanisms and to interrogate existing and novel in vitro systems for the prediction of human DILI. The current test systems employed by pharmaceutical industry are poorly predictive for drug-induced liver injury (DILI). The 'MIP-DILI' project addresses this ...
https://www.deepdyve.com/lp/springer-journals/evidence-based-selection-of-training-compounds-for-use-in-the-WMQx6W9IVx<p>The current test systems employed by pharmaceutical industry are poorly predictive for drug-induced liver injury (DILI). The 'MIP-DILI' project addresses this situation by the development of innovative preclinical test systems which are both mechanism-based and of physiological, pharmacological and pathological relevance to DILI in humans. An iterative, tiered approach with respect to ...
https://www.infona.pl/resource/bwmeta1.element.springer-doi-10_1007-S00204-016-1845-1?locale=en